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CORONAVIRUS RAPID TEST FOR DETECTION OF SARS-CoV-2 ANTIBODIES

There is fear and uncertainty around the world about the novel coronavirus (SARS-CoV-2). If an infection is suspected, a so-called PCR laboratory test has to be carried out using a swab. The possibilities for these tests are limited worldwide. With this new in-vitro Coronavirus rapid test a result can be achieved within 15 minutes using 1 – 2 drops of blood from the fingertip. The test detects the immunoglobulins IgM and IgG, which are in the blood of those affected when they are infected with the coronavirus. Thanks to the simple handling, the quick test allows a reliable diagnosis. No specific laboratory equipment is required. The test results can be described as extremely successful. In the cross-test with the PCR swab test, the rapid test showed 100% agreement in the detection of subjects who were neither acutely nor previously infected with the Covid-19 virus in 70 tested cases. This agreement is important because the rapid test has a high demarcation ability against infections with other, more common coronavirus subtypes. The test complies with European standards. Is CE and ISO certified.

SIMPLE AND SAFE PROCEDURE

Brief instructions Corona testAn acute or previous infection with the SARS-CoV-2 virus can be detected or excluded on the basis of the antibody formation. The procedure is extremely simple and safe:

1. With a lancet, blood is drawn from the fingertip by medical personnel using a pipette. Only 1-2 drops of the blood are required, which are added to the correspondingly marked field “S” on the test cassette. Two more drops of the buffer solution are also added to the “S” field. A colored line appears in the control area (C) and serves as an internal positive process control. It confirms sufficient sample volume and correct use of the Coronavirus rapid test.

2. The result is available after approx. 15-20 minutes. The test lines (IgM) and (IgG) show discoloration if the result is positive.

Interpretation of the results: If only the control line stains, no antibodies against the virus are detected. If one or both test lines are stained, there are antibodies against the virus and thus evidence of an acute or previous infection with the SARS-CoV-2 virus. A single positive IgM test line indicates infection in the early phase (4 to 10 days) , an additional positive IgG test line indicates a later phase of the disease (from 11 days) . An IgG test line alone is usually found in older infections or after surviving infections.

ABOUT CORONAVIRUS

At the beginning of January 2020, a new type of coronavirus (2019-nCoV) was identified as an infectious agent in Wuhan China. The local origin of the coronavirus epidemic in China is probably a market in the central Chinese city of Wuhan. In addition to fish, bats, snakes and other wild animals were also traded there. The virus was transmitted from animals to humans. Since then, the virus has been transmitted from person to person. Common signs of a corona infection include respiratory symptoms, fever, cough, shortness of breath and difficulty breathing. In severe cases, infection can cause pneumonia, severe acute respiratory syndrome, or kidney failure, and can even result in death. The standard recommendations to prevent the spread of infections include regular hand washing,

HOW CAN CORONAVIRUS BE TRANSMITTED?

  • In the case of close and prolonged contact:  if you keep a sick person less than 2 meters away for more than 15 minutes
  • By droplets:  If the sick person sneezes or coughs, the corona viruses can get directly onto the mucous membranes of the nose, mouth or eyes of other people
  • Over the hands:  Contagious droplets from coughing and sneezing can be on the hands. They get to your mouth, nose or eyes when you touch them

HOW DOES CORONAVIRUS RAPID TEST WORK?

To date, there is no medication or vaccination against the new coronavirus Covid-19. It will take at least 18 to 24 months until a suitable vaccine is developed, all instances of the test phases go through and checked for side effects, approved by the health authorities and then still produced and delivered in large quantities. Initial investigations have shown that if an accelerated process were possible by skipping certain phases, a vaccine can be expected in a year at the earliest. Again, extensive vaccination takes a lot of time.

For this reason, reliable tests in the coming months will be one of the most sensible measures to at least slow the further spread of the virus and thus protect risk groups in the best possible way. The newly developed rapid test can find infected people more quickly and the necessary measures can be initiated promptly (isolation, quarantine). Another very important advantage of the Coronavirus rapid test sold on Anna’s Cosmetics is the detection of immunoglobulin-G antibodies in the late or post-disease phase. The Corona rapid test thus shows whether those affected have already survived the disease or are still contagious. As a result, people can be released from quarantine more quickly and safely.

MECHANISM OF ACTION OF CORONAVIRUS RAPID TEST

Covid-19 Corona Test

On the IgM side of the test cassette, the IgM antibodies (SARS-CoV-2 specific and non-specific) of the sample form an immune complex with the monoclonal mouse anti-human IgM antibodies conjugated with gold, which are already precoated on the membrane. This immune complex moves across the test membrane.

If the sample contains SARS-CoV-2 specific IgM and this is above the minimum detection limit, then it is bound by the SARS-CoV-2 antigen already on the test membrane and a purple reddish test line appears.

If the sample does not contain SARS-CoV-2-specific IgM or if it is below the minimum detection limit, no purple reddish test line forms. On the IgG side of the test cassette, the IgG antibodies (SARS-CoV-2 specific and non-specific) form the sample with the with gold conjugated monoclonal mouse anti human IgG antibodies, which are already pre-coated on the membrane, an immune complex This immune complex moves across the test membrane.

If the sample contains SARS-CoV-2 specific IgG and this is above the minimum detection limit, then
it is bound by the SARS-CoV-2 antigen already on the test membrane and a purple reddish test line
appears. If the sample does not contain SARS-CoV- 2 contains specific IgG or is below the minimum
detection limit, no purple reddish test line forms. Regardless of whether the analyte is present in the sample, a colored line forms in the control field on both sides. The test is only valid if the control line appears.