WHAT IS CALCIUM GLUCONATE?
Derived from a patient’s own blood, PRP, short for Platelet Rich Plasma, is plasma created for therapeutic purposes that contains a high concentration of platelets. Practitioners use it to treat corneal ulcers, osteoarthritis, burns, hair loss, and ligament injuries, among other health issues. In aesthetic medicine, it’s used for facial rejuvenation treatments, such as improving fine lines and adding tone and firmness to skin. Key to the preparation of PRP is triggering platelet activation. Calcium gluconate is a mineral, a calcium salt, and it is used to activate PRP.
WHAT ROLE DOES CALCIUM GLUCONATE PLAY DURING PRP TREATMENT?
Platelets have cellular components called alpha granules that harbor growth factors. To activate PRP with calcium gluconate is to use it to induce the degranulation of those alpha granules so that they release growth factors. Growth factors are proteins that act as cell-to-cell messengers. They let one cell tell another to activate and perform specific functions that initiate and accelerate the tissue healing process. Regrettably, the human body makes fewer of these growth factors as it ages. Practitioners rely on PRP treatment to augment the number of growth factors in skin.
The first step in obtaining PRP is a blood draw from the patient. The tube is centrifuged to separate it into three parts: a bottom layer with red blood cells, a top layer with plasma, and a middle layer containing the plasma that is richest in platelets. Using a syringe, this middle layer is extracted from the tube and combined with calcium gluconate in a specific ratio of one part of calcium gluconate to a certain number of parts of plasma. Suggested ratios include 1:3, 1:5, and 1:9. This causes platelet degranulation and the release of the growth factors. It also causes the PRP to thicken, turning it into a gel. The PRP can then be injected into or applied to the face, neck, chest, the back of the hands, or the scalp, as needed.
INDICATIONS FOR USING PRP ACTIVATED WITH CALCIUM GLUCONATE
PRP is indicated for:
- Facial rejuvenation, including restoring skin texture, firmness, and smoothness
- Hair loss treatment
- Improving the appearance of scars and stretch marks
- Treatment of skin flaccidity
- Elimination of superficial wrinkles and furrows
- Use as a post-peeling or post-facial mask treatment
These vials allow for the safe and convenient activation of PRP. They:
- Are made from glass
- Contain 1000 mg of calcium gluconate (equivalent to 950 mg of calcium gluconate monohydrate and 36 mg of calcium saccharate tetrahydrate)
CALCIUM GLUCONATE BENEFITS
Activation with calcium gluconate is fundamental for PRP to achieve its complete bioregenerative action. Its principal benefit lays in its ability to release growth factors. So, PRP activated with calcium gluconate has a significantly higher concentration of growth factors than un-activated PRP.
Types of growth factors include:
- PDGF (Platelet Derived Growth Factor)
- TGF-B (Transforming Growth Factor Beta)
- EGF (Epidermal Growth Factor)
- VEFG (Vascular Endothelial Growth Factor)
- FGF (Fibroblast Growth Factor)
Growth factors have positive effects on both the dermis and the epidermis. Their functions include stimulating cell growth and differentiation and also fostering the formation of blood vessels to provide more oxygen to tissues in need of repair. Most notably, growth factors encourage the migration and proliferation of fibroblasts. Fibroblasts are the most common type of cell found in connective tissue. Moreover, they are fundamental in promoting the synthesis of collagen and elastin.
Volume & Packaging: 5 vials at 10 ml each vial
Active Substance: Calcium Gluconate 1000 mg/10 ml
Storage: Store in the original packaging. Do not refrigerate or freeze.
Calcium gluconate for PRP treatment is manufactured in Italy by Monico S.p.A.
LEARN MORE ABOUT PRP PROCEDURE BY READING MY BLOG POST “PRP INJECTIONS FOR FACE“